KPV

KPV Research Material — Alpha-MSH(11-13) Tripeptide Fragment

KPV is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (Lys-Pro-Val, CAS 67727-97-3). Despite its minimal size, KPV retains potent anti-inflammatory activity independent of the melanocortin receptor pathway, making it a widely studied tool in intestinal and immune inflammation research.

Mechanism of Action

KPV is transported into epithelial and immune cells via the PepT1 peptide transporter, giving it strong intestinal bioavailability relative to other short peptides. Intracellularly, it modulates NF-κB-linked inflammatory signaling, reducing pro-inflammatory cytokine production. This mechanism has made it a key research tool in models of intestinal barrier dysfunction and epithelial inflammation.

Research Applications

• DSS and TNBS colitis models
• Intestinal epithelial barrier and PepT1 transport studies
• NF-κB and cytokine signaling research
• Bronchial and airway epithelial inflammation studies

Specifications

• Chemical Name: Lysine-Proline-Valine (Alpha-MSH 11-13 fragment)
• CAS Number: 67727-97-3
• Molecular Formula: C16H30N4O4
• Molecular Weight: 342.43 Da
• Sequence: Lys-Pro-Val
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 5mg, 10mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.