ARA-290

ARA-290 Research Material — Helix-B-Derived Innate Repair Receptor Agonist

ARA-290 is a synthetic 11-amino-acid peptide modeled on the aqueous face of helix B of erythropoietin (EPO). It was designed to isolate EPO’s tissue-protective signaling from its hematopoietic activity, making it a widely used tool for studying the innate repair receptor independently of red-cell production.

Mechanism of Action

ARA-290 selectively engages the innate repair receptor (IRR), a heteromeric complex of the EPO receptor and the β-common receptor (CD131). Unlike full-length EPO, it does not activate the classical EPOR homodimer that drives erythropoiesis. In preclinical models, IRR engagement is associated with reduced pro-inflammatory cytokine signaling and modulation of cell-survival pathways.

Research Applications

• Innate repair receptor (EPOR/CD131) signaling and receptor-selectivity studies
• Inflammatory cytokine modulation in in-vitro and animal models
• Peripheral nerve and small-fiber models in preclinical neuropathy research
• Comparator studies against full-length EPO for non-erythropoietic signaling

Specifications

• CAS: 1208243-50-8
• Sequence: pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (pEQLERALNSS)
• Molecular formula: C51H84N16O21
• Molecular weight: ≈1257.3 Da
• Length: 11 residues
• Form: Lyophilized powder, 10mg per vial
• Purity: ≥98% (HPLC verified)

Storage & Handling

Store lyophilized material at −20°C, protected from light and moisture. Once reconstituted, store at 2–8°C and use within the timeframe appropriate to your laboratory protocol.

For laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.