Snap-8

Snap-8 Research Material — Acetyl Octapeptide-3 / SNAP-25 Fragment Analog

Snap-8 (CAS 868844-74-0) is a synthetic octapeptide analog of a SNAP-25 fragment, an extension of the widely studied Argireline (Acetyl Hexapeptide-3) research peptide. It is studied as a reversible, competitive inhibitor of SNARE-complex formation, distinguishing its mechanism from botulinum toxin, which permanently cleaves SNARE-complex proteins.

Mechanism of Action

Snap-8 competitively interferes with the assembly of the SNARE complex (comprising SNAP-25, syntaxin, and VAMP/synaptobrevin), the molecular machinery responsible for docking and fusing neurotransmitter-containing vesicles to the presynaptic membrane. By reversibly disrupting this complex, Snap-8 is studied for its ability to reduce neurotransmitter and acetylcholine release at neuromuscular junctions — without permanently cleaving or damaging the target SNARE proteins, unlike botulinum toxin.

Research Applications

• Topical and dermal research applications
• Comparative SNARE-complex biology studies
• Neuromuscular junction and acetylcholine-release research
• Comparative mechanism studies against botulinum toxin and related SNARE inhibitors

Specifications

• Chemical Name: Acetyl Octapeptide-3
• CAS Number: 868844-74-0
• Molecular Weight: ≈951 Da
• Structure: Octapeptide (SNAP-25 fragment analog)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 10mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.