VIP

VIP Research Material — Vasoactive Intestinal Peptide

VIP (Vasoactive Intestinal Peptide, CAS 40077-57-4) is a 28-amino-acid regulatory neuropeptide distributed across the gastrointestinal, respiratory, and central nervous systems. It is one of the most broadly studied neuropeptides in the secretin/glucagon peptide superfamily, with roles spanning smooth-muscle regulation, immune modulation, and central nervous system signaling.

Mechanism of Action

VIP signals primarily through VPAC1 and VPAC2 G-protein-coupled receptors, activating adenylate cyclase and elevating intracellular cAMP. This drives smooth-muscle relaxation and stimulates gastrointestinal secretion. In immune models, VIP suppresses pro-inflammatory cytokine release and influences monocyte and T-cell differentiation. In the central nervous system, VIP-expressing neurons in the suprachiasmatic nucleus play a key role in synchronizing circadian rhythms and modulating synaptic transmission.

Research Applications

• Smooth-muscle relaxation and gastrointestinal secretion studies
• Immune modulation and cytokine-suppression research
• Circadian rhythm and suprachiasmatic nucleus signaling models
• Synaptic transmission and central neuropeptide research

Specifications

• Chemical Name: Vasoactive Intestinal Peptide
• CAS Number: 40077-57-4
• Molecular Formula: C147H238N44O42S
• Molecular Weight: 3325.7 Da
• Residues: 28
• Purity: ≥97% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 5mg, 10mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.