MOTS-c

MOTS-c Research Material — Buy Mitochondrial-Derived Peptide MOTS-c (≥ 98% Purity)

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene region (MT-RNR1), classified as a mitochondrial-derived peptide (MDP). It functions in mitochondrial-to-nuclear retrograde signaling and has become a focal point of metabolic and exercise-adaptation research due to its insulin-independent effects on cellular glucose handling.

Mechanism of Action

MOTS-c activates AMPK (AMP-activated protein kinase) in an insulin-independent manner, promoting GLUT4 translocation and enhanced glucose uptake in skeletal muscle. Downstream, it upregulates regulators of mitochondrial biogenesis and dynamics, including PGC-1α, NRF1, TFAM, MFN2, and OPA1. Under metabolic or oxidative stress, MOTS-c has also been reported to translocate to the nucleus, where it regulates gene expression tied to antioxidant and stress-response programs.

Research Applications

• Skeletal muscle glucose uptake and insulin-sensitivity modeling
• Exercise-adaptation and mitochondrial biogenesis research
• Diet-induced obesity and insulin-resistance models
• Age-related mitochondrial function and physical-performance research
• Cardiometabolic and neurodegenerative disease models (preliminary)

Specifications

• Chemical Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c)
• CAS Number: 1627580-64-6
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: ≈ 2174.6 Da
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 10mg, 20mg, 40mg

Storage & Handling

Store lyophilized MOTS-c at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.