5-Amino-1MQ

5-Amino-1MQ Research Material — Buy 5-Amino-1-Methylquinolinium (NNMT Inhibitor)

5-Amino-1MQ is a cell-permeable, selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor. Unlike the peptide products in this catalog, 5-Amino-1MQ is a quinolinium-based small molecule, not a protein or peptide.

Mechanism of Action

By inhibiting NNMT, 5-Amino-1MQ is reported to preserve intracellular nicotinamide and SAM pools — substrates for NAD⁺ salvage synthesis and other methylation-dependent processes. In preclinical models this has been linked to increased cellular NAD⁺ availability and altered adipocyte differentiation programs, including a shift toward a more oxidative (“browning”-associated) phenotype in white adipocyte models.

Research Applications

• In vitro adipocyte differentiation and lipid metabolism assays
• Diet-induced obesity models (body weight/adiposity endpoints)
• Skeletal muscle stem cell (myoblast) differentiation and regeneration studies

Specifications

• Chemical Name: 5-Amino-1-methylquinolinium
• CAS Number: 42464-96-0 (commonly supplied as the chloride or iodide salt — confirm exact salt form via certificate of analysis, as this affects molecular weight)
• Molecular Formula: C₁₀H₁₁N₂⁺ (free cation)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 10mg, 20mg, 50mg

Storage & Handling

Store at −20°C, protected from light and moisture. Once reconstituted, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.