Kisspeptin-10

Kisspeptin-10 Research Material — KISS1R (GPR54) Decapeptide Agonist

Kisspeptin-10 (CAS 374675-21-5) is the shortest fully bioactive fragment of the kisspeptin family, a C-terminally amidated decapeptide agonist of the KISS1R receptor (formerly GPR54). Kisspeptin signaling sits upstream of the hypothalamic-pituitary-gonadal (HPG) axis and is a central research target in reproductive endocrinology.

Mechanism of Action

Kisspeptin-10 binds KISS1R, a Gq/11-coupled receptor expressed on GnRH neurons, triggering phospholipase C activation and downstream pulsatile gonadotropin-releasing hormone (GnRH) release. This in turn drives luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from the anterior pituitary, making Kisspeptin-10 a key upstream research tool for probing the HPG axis.

Research Applications

• Reproductive-endocrinology and HPG-axis signaling research
• Dose-dependent LH/FSH elevation studies in rodent and human models
• Oocyte-maturation-trigger protocol research
• Diagnostic challenge-testing models for hypogonadotropic hypogonadism

Specifications

• Chemical Name: Kisspeptin-10 (Metastin 45-54)
• CAS Number: 374675-21-5
• Molecular Weight: ≈1302.5 Da
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (C-terminally amidated)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 5mg, 10mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.