AOD-9604

AOD-9604 Research Material — Modified hGH Fragment 176-191

AOD-9604 is a modified fragment of the C-terminus of human growth hormone (hGH residues 177–191 plus an added tyrosine, CAS 221231-10-3) — a hexadecapeptide isolated from the growth-promoting regions of the hGH molecule. It has been studied extensively for its lipolytic activity without the somatotropic, diabetogenic, or IGF-1-raising effects associated with full-length growth hormone.

Mechanism of Action

AOD-9604 is proposed to act on fat-cell metabolism through inhibition of lipoprotein lipase and upregulation of beta-3-adrenergic receptor activity, promoting lipolysis (fat breakdown) and inhibiting lipogenesis (fat storage) in adipocyte models. Because it lacks the N-terminal region of hGH responsible for growth-promoting and blood-glucose effects, it is used as a tool to isolate hGH’s metabolic fragment activity from its broader endocrine effects.

Research Applications

• Fat-cell metabolism and adipocyte signaling studies
• Lipolysis / lipogenesis pathway research
• Comparative studies isolating hGH fragment activity from full-length hGH

Specifications

• Chemical Name: hGH Fragment 176-191
• CAS Number: 221231-10-3
• Molecular Formula: C78H123N23O23S2
• Molecular Weight: 1815.1 Da
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (YLRIVQCRSVEGSCGF)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 2mg, 5mg, 10mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.