IGF-1 LR3

IGF-1 LR3 Research Material — Long-R3 Insulin-like Growth Factor 1

IGF-1 LR3 is an engineered analog of Insulin-like Growth Factor 1 (CAS 946870-92-4), carrying an arginine-for-glutamate substitution at position 3 and a 13-residue N-terminal extension. These modifications reduce affinity for IGF-binding proteins (IGFBPs) and substantially extend the analog’s half-life relative to native IGF-1, making it a widely used comparator ligand in growth-factor signaling research.

Mechanism of Action

By resisting IGFBP sequestration, IGF-1 LR3 remains bioavailable for extended interaction with the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that activates PI3K/Akt and MAPK/ERK signaling cascades. These pathways drive cell proliferation, differentiation, and protein synthesis. Its reduced IGFBP affinity makes it a useful tool for isolating IGF-1R-mediated effects from the confounding influence of binding-protein regulation seen with native IGF-1.

Research Applications

• Growth-factor signaling and receptor-binding assays
• IGFBP interaction and sequestration studies
• In-vitro cell proliferation and differentiation models
• Comparator ligand studies against native IGF-1

Specifications

• Chemical Name: Long-R3 Insulin-like Growth Factor 1
• CAS Number: 946870-92-4
• Molecular Formula: C400H625N111O115S9
• Molecular Weight: ≈9117.6 Da
• Residues: 83
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 100mcg, 1mg

Storage & Handling

Store lyophilized at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.