Glutathione (GSH) Research Compound — Buy Reduced L-Glutathione
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH, CAS 70-18-8) is the most abundant intracellular antioxidant tripeptide in mammalian biology, present at millimolar concentrations in most cell types. As the body’s primary redox buffer, GSH is central to cellular defense against oxidative damage, free radical scavenging, xenobiotic detoxification, and immune signaling. PureBond’s reduced glutathione meets ≥98% purity standards for demanding research applications.
Mechanism of Action
Glutathione acts as a direct free radical scavenger and as a cofactor for glutathione peroxidases (GPx) and glutathione S-transferases (GST). The GSH/GSSG redox couple maintains the intracellular reducing environment. GSH also conjugates with reactive electrophiles for hepatic detoxification, participates in leukotriene synthesis, and is required for regeneration of other antioxidants including vitamins C and E. Glutathione depletion is implicated in a wide range of disease states.
Research Applications
- Oxidative stress and ROS quantification models
- Cellular redox biology and thiol chemistry studies
- Liver detoxification and hepatocyte protection research
- Immune cell function and cytokine modulation studies
- Mitochondrial membrane potential and function assays
- Neurodegeneration and neuroprotection research
Specifications
- Chemical Name: L-γ-Glutamyl-L-Cysteinylglycine (Reduced)
- CAS Number: 70-18-8
- Molecular Formula: C₁₀H₁₇N₃O₆S
- Molecular Weight: 307.32 Da
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Available Sizes: 500mg, 1000mg
Storage & Handling
Store glutathione at −20°C under inert gas or vacuum seal. Reduced glutathione is susceptible to air oxidation — minimize exposure to oxygen during weighing and reconstitution. Prepare working solutions fresh for time-sensitive assays. Use HPLC-grade or ultrapure water for reconstitution.
For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.
