CJC-1295 (DAC)

CJC-1295 with DAC Research Material — Buy CJC-1295 DAC:GRF (≥ 98% Purity)

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic, 30-residue analog of growth hormone-releasing hormone (GHRH 1-29), modified with a C-terminal maleimidopropionyl group that covalently binds circulating serum albumin. This albumin conjugation is the key structural distinction from CJC-1295 without DAC (Modified GRF 1-29) — where the non-DAC variant is cleared within minutes and produces a single pulsatile GH release, the DAC-bound form resists proteolytic degradation and renal clearance, extending plasma half-life to the order of days and producing sustained rather than pulsatile elevation of growth hormone and IGF-1.

Mechanism of Action

CJC-1295 with DAC binds the GHRH receptor, a class B GPCR expressed on pituitary somatotrophs, activating Gs-coupled adenylate cyclase to raise intracellular cAMP and drive PKA-mediated GH gene transcription and secretion. The maleimidopropionic acid DAC moiety reacts with the free thiol of Cys-34 on serum albumin, forming a stable conjugate that shields the peptide from enzymatic degradation. Because the conjugated peptide continuously occupies the GHRH receptor, downstream signaling produces a sustained (non-pulsatile) elevation in GH and IGF-1, a key distinction researchers use when studying tonic versus pulsatile secretagogue exposure.

Research Applications

• Sustained versus pulsatile growth hormone/IGF-1 axis pharmacodynamics
• Albumin-conjugation (DAC) half-life extension and bioconjugate delivery research
• Body composition and lean mass/adiposity endpoints in preclinical models

Specifications

• Chemical Name: CJC-1295 with DAC (DAC:GRF)
• CAS Number: 446262-90-4
• Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆
• Molecular Weight: ≈ 3647 Da
• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(DAC)-NH₂
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 2mg, 5mg, 10mg

Storage & Handling

Store lyophilized CJC-1295 with DAC at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.