Sermorelin

Sermorelin — GHRH Analog Research Compound (≥99% Purity)

Sermorelin is a truncated growth hormone-releasing hormone (GHRH) analog, comprising the first 29 amino acids of the natural 44-amino-acid GHRH sequence. It is among the shortest sequences studied to retain full biological activity at the GHRH receptor, and has a long-standing research history in growth hormone axis and pituitary function studies.

Mechanism of Action

Sermorelin is studied for its interaction with GHRH receptors on anterior pituitary somatotroph cells, where it may stimulate the natural, pulsatile release of endogenous growth hormone. This receptor-mediated pathway is investigated for downstream effects on IGF-1 production and cAMP/PKA signaling cascades, without directly overriding the body’s own feedback regulation of growth hormone secretion.

Research Applications

• Growth hormone axis and pituitary function research
• IGF-1 pathway and anabolic signaling studies
• Sleep-cycle and orexin regulation research
• Cardiac tissue remodeling models
• Comparative studies against other GHRH analogs and secretagogues

Specifications

• Chemical Name: Sermorelin (GHRH 1-29)
• CAS Number: 86168-78-7
• Molecular Formula: C149H246N44O42S
• Molecular Weight: ≈3358 Da
• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Available Sizes: 5mg, 10mg

Storage & Handling

Store lyophilized Sermorelin at −20°C, protected from light and moisture. Once reconstituted with Reconstitution Solution, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.