CJC-1295 Research Material — Buy CJC-1295 without DAC (Modified GRF 1-29) (≥97% Purity)
CJC-1295 without DAC (also known as Modified GRF 1-29) is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH), engineered with amino acid substitutions for enhanced resistance to enzymatic degradation. Unlike the DAC-conjugated version, this shorter-acting variant is widely used in research protocols requiring precise, pulsatile exposure patterns that mimic natural GH secretion.
Mechanism of Action
CJC-1295 acts as a GHRH receptor agonist on pituitary somatotroph cells, stimulating a amount-dependent, pulsatile release of endogenous growth hormone. This subsequently elevates hepatic and peripheral IGF-1 production. Because it works through the same receptor pathway as natural GHRH, its effects are considered physiologic rather than supraphysiologic, and its short half-life allows researchers to preserve the natural pulsatility of the GH axis — a key variable in secretagogue research.
Research Applications
- Growth hormone axis and pituitary somatotroph function studies
- IGF-1 signaling and downstream metabolic pathway research
- Body composition and lean mass regulation models
- Sleep architecture and nocturnal GH pulse research
- Synergy studies when combined with ghrelin-mimetic secretagogues (e.g. Ipamorelin)
Specifications
- Chemical Name: CJC-1295 without DAC (Modified GRF 1-29)
- CAS Number: 863288-34-0
- Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
- Molecular Weight: 3367.9 Da
- Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
- Purity: ≥97% (HPLC verified)
- Form: Lyophilized powder
- Available Sizes: 5mg, 10mg
Storage & Handling
Store lyophilized CJC-1295 at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.
For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.
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