Retatrutide + Cagrilintide Blend

Retatrutide + Cagrilintide Blend Research Material — Buy Retatrutide / Cagrilintide (≥ 97% Purity)

This blend combines Retatrutide, a unimolecular triple agonist of the GIP, GLP-1, and glucagon receptors, with Cagrilintide, a long-acting, fatty-acid-conjugated amylin receptor agonist. The two compounds act on distinct hormonal axes — incretin/glucagon signaling and amylin signaling — that are studied together for their complementary effects on appetite regulation and energy balance.

Mechanism of Action

Retatrutide engages the GIP, GLP-1, and glucagon receptors simultaneously, combining GLP-1-mediated appetite suppression and insulinotropic signaling, GIP-mediated insulin sensitization, and glucagon-receptor-driven increases in energy expenditure and lipolysis. Cagrilintide selectively activates amylin (AMY) receptors — calcitonin receptor/RAMP complexes — slowing gastric emptying, promoting satiety, and suppressing glucagon secretion through a pathway that is complementary to, rather than overlapping with, incretin receptor agonism. The blend is studied for the combined downstream effect of engaging both signaling systems concurrently.

Research Applications

• Combined incretin (GIP/GLP-1/glucagon) and amylin receptor signaling research
• Appetite regulation and energy balance models
• Body weight and adiposity endpoints in preclinical models

Specifications

• Components: Retatrutide + Cagrilintide
• CAS Numbers: Retatrutide 2381272-15-5; Cagrilintide 2138861-62-4
• Purity: ≥97% (HPLC verified, each component)
• Form: Lyophilized powder blend
• Available Sizes: 12.5mg / 2.5mg, 25mg / 5mg (Retatrutide / Cagrilintide)

Storage & Handling

Store lyophilized blend at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.