Eloralintide

Eloralintide | Metabolic Research Peptide

Eloralintide is a synthetic, long-acting amylin receptor agonist peptide supplied for in-vitro and laboratory research. It is a modified amylin analog carrying a C20 fatty diacid moiety on a lysine side chain, a design feature used to extend half-life in research models. It is studied as a tool compound for amylin receptor signaling and related metabolic pathways.

Mechanism of Action

Eloralintide activates amylin receptors, which are heterodimers of the calcitonin receptor (CTR) and a receptor activity-modifying protein (RAMP). In preclinical research models, amylin receptor activation is investigated in the context of satiety signaling, energy balance, and glucose homeostasis pathways.

Research Applications

• Amylin receptor (CTR/RAMP) binding and cell-based signaling assays
• Receptor selectivity and calcitonin receptor cross-activity studies
• Comparative studies against native amylin, pramlintide, and cagrilintide analogs
• Pharmacokinetic and albumin-binding studies of fatty-diacid-lipidated peptides
• Preclinical metabolic pathway and energy balance models

Specifications

• CAS: 2883634-40-8
• Molecular formula: C201H319N49O65S2
• Molecular weight: ≈4526.1 Da
• Modifications: C-terminal amide, Cys2–Cys7 methylene bridge, C20 fatty diacid (γGlu-γGlu linker) on Lys
• Form: lyophilized powder, 10mg per vial
• Purity: verified by HPLC; lot-specific analysis available on request

Storage & Handling

Store lyophilized material sealed at −20°C, protected from light and moisture. Once reconstituted, store at 2–8°C and use within the timeframe appropriate to your laboratory protocol. Avoid repeated freeze-thaw cycles.

For laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.