CJC-1295 + Ipamorelin Blend

CJC-1295 + Ipamorelin Blend Research Material — Buy CJC-1295 (no DAC) / Ipamorelin (≥ 97% Purity)

This blend combines CJC-1295 without DAC (Modified GRF 1-29), a short-acting GHRH receptor agonist, with Ipamorelin, a selective ghrelin receptor (GHS-R1a) agonist. The two peptides act on distinct receptors that converge on pituitary somatotroph GH release, and are frequently co-administered in research settings to study synergistic (rather than merely additive) growth hormone secretagogue effects.

Mechanism of Action

CJC-1295 (no DAC) binds the GHRH receptor, a Gs-coupled class B GPCR, raising intracellular cAMP and driving PKA-mediated GH gene transcription and pulsatile release. Ipamorelin binds GHS-R1a, the ghrelin receptor, coupling to Gq/11 to activate phospholipase C-β and mobilize intracellular calcium, triggering a separate, complementary GH-release pathway with high selectivity (minimal ACTH/cortisol/prolactin co-release). Because the two peptides act through independent receptor systems that both converge on somatotroph GH exocytosis, combined administration is studied for synergistic amplification of the GH pulse relative to either peptide alone.

Research Applications

• Synergistic dual-receptor (GHRH-R + GHS-R1a) growth hormone secretagogue research
• Pituitary GH pulse amplitude and pulsatility studies
• IGF-1 axis and downstream metabolic signaling research

Specifications

• Components: CJC-1295 without DAC (Modified GRF 1-29) + Ipamorelin
• CAS Numbers: CJC-1295 (no DAC) 863288-34-0; Ipamorelin 170851-70-4
• CJC-1295 Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
• Ipamorelin Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
• Purity: ≥97% (HPLC verified, each component)
• Form: Lyophilized powder blend
• Available Sizes: 5mg / 5mg, 10mg / 10mg (CJC-1295 / Ipamorelin)

Storage & Handling

Store lyophilized blend at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. All handling should be performed under sterile laboratory conditions by trained research personnel.

For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.